Modulation of fibroblast proliferation by oxygen free radicals

Modulation of fibroblast proliferation by oxygen free radicals.

The major unexplained phenomenon in fibrotic conditions is an increase in replicating fibroblasts. In this report we present evidence that oxygen free radicals can both stimulate and inhibit proliferation of cultured human fibroblasts, and that fibroblasts themselves release superoxide (O2.-) free radicals. Fibroblasts released O2.- in concentrations which stimulated proliferation, a finding co...

Biochemistry of Oxygen and Its Free Radicals

Thrombolytic treatment in acute myocardial infarction achieves coronary patency in most patients.' Mortality in groups treated early after the onset of symptoms is significantly reduced,' but left ventricular function does not always improve.5 Myocardial necrosis during the period of vessel occlusion is partly responsible for the irreversible ventricular impairment that occurs even when the ves...

Oxygen free radicals and retinopathy of prematurity.

Dipyridamole inhibits platelet aggregation induced by oxygen-derived free radicals.

Pyrogallol (a generator of superoxide anions) caused 50% increase in platelet aggregation induced by 400 microM of arachidonic acid. Dipyridamole did not produce a statistically significant inhibition of arachidonic-acid induced platelet aggregation, but it caused 100% inhibition of pyrogallol-stimulated platelet aggregation. Ferrous salts (Fe2+) induced 34% platelet aggregation which was inhib...

Oxygen free radicals and congestive heart failure.

Plasma lipid peroxides (malondialdehyde) and thiols were measured in 45 patients with congestive heart failure and 45 controls. Malondialdehyde concentrations were significantly higher in the patients with congestive heart failure (median 9.0 nmol/ml interquartile range (IQR) 7.9-10.2) than in the controls (median 7.7 nmol/ml (IQR 6.9-9.2)). Plasma thiols were significantly lower in congestive ...